产品货号：
Z39539
中文名称：
KMT5A抗体
英文名称：
Anti-KMT5A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KMT5A Antibody |
| 指标别名 | H4 K20 HMTase SETD8;KMT5A;Lysine N methyltransferase 5A;PR Set7;PR/SET07;PRSET7;SET07;SET8;SETD8 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | KMT5A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human KMT5A/SETD8/Pr-SET7 Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins.Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1).H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.Mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. |
| 实际分子量 | 50KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SET domain-containing lysine methyltransferase 8 (SET8),also known as PR/SET domain-containing protein 7 (PR/SET7),is a member of a family of histone lysine methyltransferases,each of which contains a conserved catalytic SET domain originally identified in Drosophila Su[var]3-9,Enhancer of zeste,and Trithorax proteins (1-3).SET8 is a single-subunit enzyme that mono-methylates histone H4 on Lys20,preferably on nucleosomal substrates (1-3).SET8 protein levels and Histone H4 Lys20 methylation are cell cycle regulated,both increasing in S phase and peaking at G2/M phase (4,5).SET8 interacts with the PCNA protein,associates with sites of active DNA synthesis,and is required for DNA replication and genome stability during S phase (5-7).Inhibition of SET8 using shRNA or siRNA results in arrest of replication forks,induction of double-stranded DNA breaks,and a Chk1-mediated cell-cycle arrest in S and G2/M phases of the cell cycle (6,7).Furthermore,SET8 methylates p53 on Lys382,down regulating the pro-apoptotic and checkpoint activation functions of p53 (8).In response to DNA damage,SET8 expression levels decrease,allowing p53 to activate checkpoints and/or apoptosis (8).Both the methylation of histone H4 Lys20 and p53 appear to be important for the functions of SET8 in S phase. |
| Uniprot ID | Q9NQR1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：KMT5A抗体，KMT5A单抗，Anti-KMT5A Antibody